Endocrine Abstracts

Recent molecular studies suggest a role of ectopic G protein coupled receptors in primary aldosteronism (PA). The clinical relevance of these findings is not known. We therefore combined expression profiling and a clinical testing of hormone responsiveness in patients with primary aldosteronism. Sixteen tissues from aldosterone producing adenomas and 6 normal adrenal glands were subjected to a quantitative PCR for determination of mRNA expression levels of AT2R, GIPR, MC2R, Gn...